Advanced oral care. Daily dental treats. Dog treats. As effective as brushing (When fed daily, Milk-Bone Brushing Chews are as effective as brushing a dog's teeth twice a week based on the reduction of tartar build-up and bad breath. The Veterinary Oral Health Council recommends daily tooth brushing for optimal effectiveness). Loved since 1908. Good oral care helps your dog live a healthy, happy life. See bottom panel for details. Nubs & ridges designed to help clean like bristles on a toothbrush. Fights tartar build-up and bad breath. Daily Milk-Bone Brushing Chews. Yearly veterinary dental checkup. Dental twist bone helps clean even hard to reach back teeth and down to the gumline. Veterinary Oral Health Council. VOHC Accepted. Helps control tartar. See bottom panel for product information. For dogs 25-49 lbs. Not suitable for dogs less than 25 lbs, greater than 49 lbs or dogs less than 6 months of age. Fortified with 12 essential vitamins and minerals, including calcium to help support strong bones and teeth. Comments or questions? Call 1-888-Milkbone (645-5266), weekdays. Please provide product manufacturing code. www.MilkBone.com. Calorie Content (Calculated): Metabolizable energy (ME) 2580 kcal/kg; 65 kcal/piece. Produced in Topeka, Kansas, USA.